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Emep MUPS 40mg Tablet 10pcs
MUPS (Multiple-Unit Pellet System) technology combines the advantages of tablets and pellet-filled capsules:
- Ensures greater bioavailability.
- Promotes uniform emptying of micro-pellets from the stomach to the intestine for faster drug release.
- Reduces dose-dumping risks and minimizes local irritation.
- Offers consistent and controlled pharmacological action with once-daily dosing.
- Improves drug absorption and minimizes plasma concentration fluctuations.
- Provides better esophageal residence time reduction compared to capsules.
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✅ Description:
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✔️ Emep MUPS is indicated for:
- Gastro-esophageal Reflux Disease (GERD)
- Risk reduction of NSAID-associated gastric ulcers
- H. pylori eradication (as part of triple therapy)
- Zollinger-Ellison syndrome and idiopathic hypersecretion
Use as directed by a registered physician.
✔️ Pharmacology
Esomeprazole, a proton pump inhibitor, blocks the hydrogen-potassium ATPase enzyme system (proton pump) in gastric parietal cells, effectively reducing gastric acid secretion. It is used for the short-term treatment of gastric and duodenal ulcers and for preventing NSAID-induced gastric ulcers.
✔️ Dosage & Administration
Erosive Esophagitis
- Adults (≥18 years): 40 mg once daily for 4 weeks.
- Children (12-18 years): 40 mg once daily for 4 weeks.
Maintenance of Healing (Erosive Esophagitis)
- Adults (≥18 years): 20 mg once daily.
- Children (12-18 years): 20 mg once daily.
Risk Reduction of NSAID-associated Gastric Ulcers
- Adults (≥18 years): 20 mg once daily for 4-8 weeks.
H. pylori Eradication (with Amoxicillin and Clarithromycin)
- Adults (≥18 years): 20 mg twice daily for 7 days.
- Children (12-18 years): 20 mg twice daily for 7 days.
Zollinger-Ellison Syndrome & Idiopathic Hypersecretion
- Adults (≥18 years): 40-80 mg twice daily.
Children (1-11 years)
- Erosive esophagitis:
- <20 kg: 10 mg once daily for 8 weeks.
- ≥20 kg: 10-20 mg once daily for 8 weeks.
- Maintenance: 10 mg once daily.
Not approved for children below 1 year.
✔️ Administration
- Swallow the tablets whole with liquid.
- Do not chew or crush the tablets.
- Alternatively, disperse the tablet in half a glass of non-carbonated water (not mineral water). Stir until disintegrated, drink immediately, and rinse the glass with more water to ensure full dose intake.
✔️ Interactions
- Metabolism: Primarily metabolized by CYP2C19 and CYP3A4.
- CYP Interactions: No clinically significant interactions with CYP1A2, 2A6, 2C9, 2D6, or 3A4.
- Drug Absorption: This may affect drugs dependent on gastric pH for absorption (e.g., ketoconazole, iron salts, digoxin).
- Combination Therapy: Increases plasma levels of Emep MUPS and 14-hydroxy clarithromycin when co-administered with clarithromycin and amoxicillin.
✔️ Side Effects
Common side effects include:
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
No significant differences in side effects were observed between short-term and maintenance treatment (up to 12 months).
✔️ Use During Pregnancy & Lactation
- Use with caution during pregnancy.
- It is unclear if Esomeprazole or its metabolites are excreted in human breast milk.
✔️ Contraindications
- Known hypersensitivity to Esomeprazole or any component of the formulation.
✔️ Precautions & Warnings
- Use cautiously in patients with severe liver or renal impairment.
- Prolonged use (>1 year) may increase the risk of fractures (hip, wrist, spine).
✔️ Storage Conditions
- Store below 25°C in a cool, dry place.
- Protect from light.
- Keep out of reach of children.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
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lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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